Not exciting, but interesting to me

During last weekend oncall, 47M came in with 10 hr history of chest pain. Central chest pain, 8/10. radiated to lt shoulder.

PMHx: Nil significant, No DM, No HTN

FHx: 3 brother died of MI at the age of 47, 49, 52. Sister had heart attack, but she survived

SHx: never smoke, occasioanal drinker

Cholesterol: DK

O/e Still on pain 3-4/10 on GTN as A&E started

CVS: NAD

Resp: NAD

Abd: NAD

Legs: NAD

ECG: T flat in lateral leads, otherwise normal

CXR: NAD

Trop I on Adm (10hr) 0.05

Interestingly 12 hr Trop I came back as 1.5.

So he is for CCU and to continue with ACS protocol. He needs agniography / and angioplasty

2 Questions in my mind

1. Why Troponin I soared from 0.05 to 1.5 in 2 hr time, instead of gradually rose?

2. What would be the genetic association of the patient's condition?