Reducing the risk of venous thromboembolism

Venous thromboembolism: reducing the risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism) in inpatients undergoing surgery New NICE guide line : April 2007 [url=http://www.nice.org.uk/CG46]Click here[/url]

Aspirin, dipyridamole and secondary prevention of stroke

My consultant neurologist normally prescribes the patients with stroke: Aspirin, Ramipril,Statin.This ESPS-2 shows there is a benefit of adding dipyridamole. It was done in 1988. so there should be more research data somewhere. [b]European Stroke Prevention Study 2 (ESPS-2):[/b] After doing randomised, double-blind, placebo-controlled trial of 6602 patients, it was discovered that the 24-month stroke rate was 12.9% in the aspirin-alone group, 13.2% in the dipyridamole-alone group, 9.9% in the combination group and 15.8% in the placebo group. Stroke risk was significantly reduced by 18.1% in the aspirin-alone group, by 16.3% in the dipyridamole-alone group, and by 37.0% in the combination group compared to the placebo group. The results regarding the endpoint of stroke or death were similar but there was no significant difference among the groups for the endpoint of death . [url=http://www.ncbi.nlm.nih.gov]source[/url]

Early management of suspected meningitis

This is the guide lines for Early Management of Suspected Bacterial Meningitis and Meningococcal Septicaemia in Immunocompetent Adults [url=http://www.britishinfectionsociety.org/Adult_men_early_poster%202004.pdf]Click here[/url]

Pandemic Influenza management guidelines 2007

Clinical management of patients with an influenza-like illness during an influenza pandemic Provisional guidelines from the British Infection Society British Thoracic Society Health Protection Agency in collaboration with the Department of Health Version 11, updated on 2 October 2006 [url=http://www.britishinfectionsociety.org/Pandemic%20guidelines%202007.pdf]Guidelines[/url]

Switching patients from atorvastatin to simvastatin and losartan to candesartan

This is not exciting but interesting topic. I think. You may check [url=http://www.onmedica.net/content.asp?t=2&c=4462&pid=84cdcccdcccec6c9bbd2c8bccfcfd2cbbbbdced2c6bbc6bcd2becfcebecdbac8beccb9c6c882]here[/url]

TIMI RISK SCORE for UA/NSTEMI

Age ≥ 65 years? 1
> 3 Risk Factors for CAD? 1
Known CAD (stenosis ≥ 50%)? 1
ASA Use in Past 7d? 1
Severe angina (≥ 2 episodes w/in 24 hrs)? 1
ST changes ≥ 0.5mm? 1
+ Cardiac Marker? 1

Risk Factors:

Adjuvant Chemotherapy With Gemcitabine vs Observation in Patients Undergoing Curative-Intent Resection of Pancreatic Cancer

Postoperative gemcitabine significantly delayed the development of recurrent disease after complete resection of pancreatic cancer compared with observation alone. These results support the use of gemcitabine as adjuvant chemotherapy in resectable carcinoma of the pancreas. [url=http://jama.ama-assn.org/cgi/content/abstract/297/3/267]Full article on JAMA[/url]

Streptococcus suis

The main source of Streptococcus suis is pig across the world.It can be spread from sick or carrier pig to human who has a close contact with it.The organism causes meningitis, septicaemia, endocarditis, arthritis, and septic shock in both hosts and mortality is high. REF: [url=http://www.thelancet.com/journals]http://www.thelancet.com/journals[/url]

Long-term Proton Pump Inhibitor Therapy and Risk of Hip Fracture

Many consider that Proton pump inhibitors (PPIs) may interfere with calcium absorption through induction of hypochlorhydria but they also may reduce bone resorption through inhibition of osteoclastic vacuolar proton pumps.After doing the controlled trial on 13 556 hip fracture cases and 135 386 controls, conculstion is "Long-term PPI therapy, particularly at high doses, is associated with an increased risk of hip fracture." Full article @ http://jama.ama-assn.org/cgi/content/abstract/296/24/2947

How long should women stay on bisphosphonates for?

[b]Effects of Continuing or Stopping Alendronate After 5 Years of Treatment[/b] Women who discontinued alendronate after 5 years showed a moderate decline in BMD and a gradual rise in biochemical markers but no higher fracture risk other than for clinical vertebral fractures compared with those who continued alendronate. These results suggest that for many women, discontinuation of alendronate for up to 5 years does not appear to significantly increase fracture risk. However, women at very high risk of clinical vertebral fractures may benefit by continuing beyond 5 years. Full Article on JAMA @ http://jama.ama-assn.org/cgi/content/abstract/296/24/2927
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